In vivo induction for enhanced function of isolated hepatocytes
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United States of America Patent
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Jan 30, 2007
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N/A
app pub date -
Jun 27, 2003
filing date -
Jul 22, 1999
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Expired
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Abstract
The invention features a liver cell culture comprising hepatocytes that have increased detoxification enzyme activity when isolated from a liver of a donor that had been administered at least one induction agent prior isolation of hepatocyte cells. The induced hepatocytes are used in a bioreactor and cultured to produce hepatocyte cell products or metabolize toxins added to the culture. The bioreactor is, or is an integral part of, a liver assist device used to treat a patient in need of liver assist.
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