Angiogenesis inhibitors
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United States of America Patent
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Jan 23, 2007
Grant Date -
Oct 2, 2003
app pub date -
May 16, 2002
filing date -
Mar 29, 2002
priority date (Note) -
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Abstract
A method for treating an angiogenesis-related disorder. The method includes administrating to a subject in need thereof an effective amount of a compound of the formula: ##STR00001## Each of Ar.sub.1, Ar.sub.2, and Ar.sub.3, independently, is phenyl, thienyl, furyl, pyrrolyl, pyridinyl, or pyrimidinyl; each of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6, independently, is R, nitro, halogen, C(O)OR, C(O)SR, C(O)NRR', (CH.sub.2).sub.mOR, (CH.sub.2).sub.mSR, (CH.sub.2).sub.mNRR', (CH.sub.2).sub.mCN, (CH.sub.2).sub.mC(O)OR, (CH.sub.2).sub.mCHO, (CH.sub.2).sub.mCH.dbd.NOR, or R.sub.1 and R.sub.2 together, R.sub.3 and R.sub.4 together, or R.sub.5 and R.sub.6 together are O(CH.sub.2).sub.mO, in which each of R and R', independently, is H or C.sub.1.about.C.sub.6 alkyl; and m is 0, 1, 2, 3, 4, 5, or 6, and n is 0, 1, 2, or 3.
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