Adjuvant-containing vaccines
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United States of America Patent
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Jan 16, 2007
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app pub date -
Oct 2, 2000
filing date -
Apr 3, 1998
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Abstract
This invention provides a DNA vaccine which comprises a naked DNA incorporating and expressing in vivo a nucleotide sequence encoding an antigenic polypeptide, preferably a gene of a pathogenic agent, and at least one adjuvant compound chosen from the polymers of acrylic or methacrylic acid and copolymers of maleic anhydride and alkenyl derivative. The adjuvant compound is preferably a carbomer or an EMA.RTM.. This invention also provides a method of enhancing a DNA vaccine and/or the immunogenicity of a DNA vaccine.
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