Method for the production of (r)- and (S)-8-chloro-6-hydroxyoctanic acid alkyl esters by enzymatic reduction
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United States of America Patent
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Jan 2, 2007
Grant Date -
Feb 10, 2005
app pub date -
Oct 14, 2002
filing date -
Oct 23, 2001
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Expired
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Abstract
The invention relates to a method for the production of (R)- or (S)-8-chloro-6-hydroxyoctanoic acid alkyl esters of the general formula (R)-II or (S)-II ##STR00001## in which R has the meaning C.sub.1-4-alkyl, from 8-chloro-6-oxooctanoic acid alkyl esters of the general formula I ##STR00002## in which R has the above meaning, by enzymatic reduction using alcohol dehydrogenases, such as Lactobacillus brevis or Thermoanaerobium brokii, in the presence of cofactor regeneration systems.The resulting (R)- and (S)-8-chloro-6-hydroxyoctanoic acid esters can be converted in a known manner into (R)-.alpha.-lipoic acid and (S)-.alpha.-lipoic acid, respectively.
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