Non-toxic immune stimulating enterotoxin compositions
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United States of America Patent
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Dec 12, 2006
Grant Date -
Feb 3, 2005
app pub date -
Aug 20, 2004
filing date -
Dec 2, 1997
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Pyrogenic toxins, such as staphylococcal enterotoxins, modified in the disulfide loop region are provided. The modified toxins retain useful biological properties but have substantially reduced toxicity compared to the corresponding unmodified native toxin. The native pyrogenic toxins are typically modified by deletions within the disulfide loop region to produce modified enterotoxins having 100-fold or greater decrease in toxicity.
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