Reagents and methods for mycophenolic acid immunoassay
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United States of America Patent
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Nov 21, 2006
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app pub date -
Aug 11, 2005
filing date -
Aug 12, 2004
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Abstract
The invention teaches derivatives of mycophenolic alcohol and methods of preparing immunogens and other conjugates useful in immunoassays for quantitatively measuring concentrations of mycophenolic acid (MPA) and/or active metabolites of MPA in patient specimens. Antibodies produced from the disclosed immunogens capable of binding to MPA with cross-reactivity of no more than 5% with inactive metabolites and commonly co-prescribed drugs. Further, immunoassays for measuring the concentration of MPA using such antibodies are taught.
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