Pyrrolopyrimidines and related analogs as HSP90-inhibitors
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United States of America Patent
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Nov 21, 2006
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Sep 20, 2004
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Sep 18, 2003
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Abstract
The present invention provides compounds represented by Formula I. R.sub.0 is selected from hydrogen, halogen, lower alkyl, --SR.sup.8, --OR.sup.8, --CN, and --NHR.sup.8, R.sub.1 is halogen, or lower alkyl; R.sub.2 is --NHR.sup.8; R.sub.3 is selected from the group consisting of hydrogen, halogen, --SR.sup.8, --OR.sup.8, --CN, --C(O)R.sup.9, --C(O)OH, --NO.sub.2, --NR.sup.8R.sup.10, lower alkyl, lower alkenyl, lower alkynyl, lower perhaloalkyl, aryl, heteroaryl, alicyclic and heterocyclic, all optionally substituted, and R.sub.5 is aryl, heteroaryl, alicyclic, or heterocyclic: ##STR00001##
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