Process for the enantioselective reduction of 8-chloro-6-oxo-octanoic acid alkyl esters
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United States of America Patent
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Nov 14, 2006
Grant Date -
Sep 25, 2003
app pub date -
Jul 20, 2001
filing date -
Jul 27, 2000
priority date (Note) -
Expired
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Abstract
The invention relates to a process for the production of (R)- or (S)-8-chloro-6-hydroxyoctanoic acid alkyl esters of the general formula (R)-II or (S)-II, ##STR00001## in which R means C.sub.1-4 alkyl, from 8-chloro-6-oxo-octanoic acid alkyl esters of the general formula I, ##STR00002## in which R has the above meaning.The desired enantiomers are produced biocatalytically in an enantioselective reduction, wherein as desired the strains Mucor racemosus are used for (S)-II compounds and Geotrichum candidum for (R)-II compounds.The resultant esters may, in known manner, be converted stereospecifically into (R)-.alpha.-lipoic acid.
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