Topoisomerase type II gene polymorphisms and their use in identifying drug resistance and pathogenic strains of microorganisms
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United States of America Patent
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Nov 14, 2006
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Nov 17, 1998
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Nov 17, 1998
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Abstract
Novel polymorphisms of prokaryotic topoisomerase type II Gyr A, Gyr B and parC gene loci are provided. These polymorphisms differentiate very closely related organisms and provide a means to identify pathogenicity and drug resistance. For example, drug resistance such as resistance to methicillin, a drug which is not metabolically tied to topoisomerase function, may be determined by polymorphisms in the Gyrase A locus. Identification of such drug resistance by such unrelated loci is indicative of heretofore unrecognized [sub]species of Staphylococcus aureus.
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