Composition and method for inhibiting platelet aggregation
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United States of America Patent
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Nov 7, 2006
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app pub date -
Mar 30, 2004
filing date -
Aug 21, 2000
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Abstract
This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis. The method comprises administering to a subject a pharmaceutical composition comprising a therapeutic effective amount of P2Y.sub.12 receptor antagonist compound, wherein said amount is effective to bind the P2Y.sub.12 receptors on platelets and inhibit ADP-induced platelet aggregation. The P2Y.sub.12 receptor antagonist compounds useful for this invention include mononucleoside 5'-monophosphates, mononucleoside polyphosphates, and dinucleoside polyphosphates of general Formula I, or salts thereof. The present invention also provides novel compounds of mononucleoside 5'-monophosphates, mononucleoside polyphosphates, and dinucleoside polyphosphates. The present invention further provides pharmaceutical formulations comprising mononucleoside 5'-monophosphates, mononucleoside polyphosphates, or dinucleoside polyphosphates.
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