Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D.sub.4 antagonists
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United States of America Patent
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Oct 24, 2006
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N/A
app pub date -
Sep 13, 2000
filing date -
Sep 14, 1999
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Expired
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Abstract
The compounds are of the class thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives, useful as D.sub.4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D.sub.4 receptor. These conditions comprise, for example, Attention Deficit Hyperactivity Disorder, Obsessive-Compulsive Disorder, Psychoses, Substance Abuse, Substance Dependence, Parkinson's Disease, Parkinsonism, Tardive Diskinesia, Gilles de la Tourette Syndrome, Conduct Disorder, and Oppositional Defiant Disorder. A further aspect of the invention is to provide a pharmaceutical composition, intermediates, and a method of making said class of compounds.
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