Compositions involving M-RIP, and related methods for screening for anti-hypertensive agents, and uses thereof
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United States of America Patent
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Oct 17, 2006
Grant Date -
Sep 16, 2004
app pub date -
Nov 17, 2003
filing date -
Nov 15, 2002
priority date (Note) -
Expired
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Abstract
The present invention relates to screening methods that make use of Myosin Phosphatase-Rho interacting Protein (M-RIP) for the identification of novel therapeutics for hypertension and hypertensive conditions. Also disclosed are methods for treating or preventing hypertension or hypertensive conditions by administering to a mammal a therapeutically effective amount of an agent that reduces the level or activity of M-RIP. According to this invention, the agent decreases contractile and increases relaxant effects of smooth muscle cells, ultimately decreasing the systemic blood pressure of a mammal. For example, the agent may reduce binding of M-RIP to myosin phosphatase, RhoA, or both.
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