Aryl and heteroaryl compounds and methods to modulate coagulation
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United States of America Patent
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Oct 17, 2006
Grant Date -
Jun 10, 2004
app pub date -
Aug 8, 2003
filing date -
Aug 9, 2002
priority date (Note) -
Expired
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Abstract
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as antagonists, or more preferably, partial antagonist of factor IX and thus, may be used to inhibit the intrinsic pathway of blood coagulation. The compounds are useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway utilizing factor IX. Such diseases or disease states include stroke, myocardial infarction, aneurysm surgery, and deep vein thrombosis associated with surgical procedures, long periods of confinement, and acquired or inherited pro-coagulant states.
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