Method of modulating tetrotodoxin-resistant sodium channel
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United States of America Patent
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Oct 17, 2006
Grant Date -
May 22, 2003
app pub date -
Aug 1, 2002
filing date -
Oct 11, 1995
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Abstract
The present invention relates to a voltage-gated sodium channel present in peripheral nerve tissue that is tetrodotoxin-resistant. One aspect of the present invention is purified and isolated DNA encoding this sodium channel. Another aspect of the present invention is the recombinant protein expressed by this DNA, expression vectors comprising the DNA sequence, and host cells transformed with these expression vectors. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-resistant sodium channel as a therapeutic target for compounds to treat disorders of the peripheral nervous system.
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