Nucleic acid encoding vitamin D receptor related polypeptide
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United States of America Patent
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Oct 10, 2006
Grant Date -
Feb 13, 2003
app pub date -
Aug 31, 1998
filing date -
Oct 14, 1997
priority date (Note) -
Expired
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Abstract
The present invention relates to novel vitamin D receptor related (VDRR) polypeptides, and formulations containing the same. Nucleic acid sequences encoding the VDRR polypeptides, expression vectors containing such sequences and host cells transformed with such expression vectors are also disclosed, as are methods for the expression of the novel VDRR polypeptides of the invention. The invention further relates to VDRR polypeptides for use as medicaments, and use of substances affecting VDRR signal transduction for the manufacture of medicaments for treating metabolic, proliferative or inflammatory conditions. The present invention also relates to methods for identifying clones encoding a VDRR polypeptide, methods for identifying ligands to a VDRR and methods for identifying substances for treatment of conditions affected by a VDRR polypeptide. More specifically, the novel VDRR polypeptide can be the polypeptide designated VDRR.gamma., which may be regulated by any small chemical molecule similar in structure to known ligands for nuclear receptors.
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