Modified TNF-alpha molecules, DNA encoding such and vaccines comprising such modified TNF-alpha and DNA
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United States of America Patent
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Oct 10, 2006
Grant Date -
N/A
app pub date -
Apr 15, 1998
filing date -
Apr 15, 1997
priority date (Note) -
Expired
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Abstract
A modified human TNF.alpha. molecule is capable of raising neutralizing antibodies towards unmodified human TNF.alpha. following administration of the modified TNF.alpha. to a human host, wherein one or more peptide fragments of the human TNF.alpha. molecule has been substituted by one or more peptides containing immunodominant T cell epitopes or a truncated form of the molecule containing the immunodominant epitope and one or both flanking regions of the human TNF.alpha.-molecule containing at least one TNF.alpha. B cell epitope, wherein the substitution introduces a substantial change in the amino acid sequence of any one of the strands of the front .beta.-sheet, in any one of the connecting loops, or in any one of the B', I, or D strands of the back .beta.-sheet.
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