Process for the preparation of optically active 7-substituted-3-(2-aminopropyl)indole derivatives and intermediates therefor
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United States of America Patent
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Oct 3, 2006
Grant Date -
Sep 25, 2003
app pub date -
Mar 30, 2001
filing date -
Apr 4, 2000
priority date (Note) -
Expired
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Abstract
Disclosed are a process for preparation of an optically active 7-substituted 3-(2-aminopropyl)indole compound and an intermediate therefor. In the above preparation process, 7-substituted indole is reacted with L- or DL-serine in the presence of a tryptophan-synthesizing enzyme originating in microorganisms to form corresponding 7-substituted L-tryptophan, and it is subjected, if necessary, to reduction, protection, exchange and elimination.
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