Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions
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United States of America Patent
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Sep 19, 2006
Grant Date -
Jan 15, 2004
app pub date -
May 28, 2003
filing date -
May 28, 2002
priority date (Note) -
Expired
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Abstract
Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I ##STR00001## or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.7 are defined in the specification, Z is SO or SO.sub.2, and Ar is an aromatic or heteroaromatic group as defined herein.
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