Stereoselective methods for the preparation of nucleosides
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United States of America Patent
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Sep 19, 2006
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app pub date -
Jun 14, 2002
filing date -
Jun 15, 2001
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Abstract
A process for producing predominantly cis nucleosides or nucleoside analogues and derivatives of formula (A): ##STR00001## wherein R1 is a pyrimidine base or a pharmaceutically acceptable derivative thereof and Q is oxygen, carbon or sulphur, comprising a coupling step of the pyrimidine base with a molecule of formula (B) described herein in a suitable coupling solvent, in the presence of catalytic amounts of an element or combination of elements of groups IB or IIB of the periodic table, a tertiary amine and a Lewis acid to obtained an intermediate of formula (D) which is deprotected in the subsequent step to generate the product of formula (A).
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