Vasoconstrictor cannabinoid analogs

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United States of America Patent

PATENT NO 7109245
APP PUB NO 20040236153A1
SERIAL NO

10486810

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Abstract

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Methods and compounds for reversing pathological vasodilation of blood vessels, for example vasodilation caused by activation of CB1-like receptors, by administering to a subject a therapeutically effective amount of a compound sufficient to induce vasoconstriction, the compound comprising: ##STR00001## wherein dashed lines independently represent either a single or a double bond, R.sub.1 is a lower alkyl, R.sub.2 is a lower alkyl, R.sub.3 is a lower alkyl or halogen, R.sub.4 is a lower alkyl or hydrogen, R.sub.5 is a lower alkyl or hydrogen, R.sub.6 is a hydrogen, lower alkyl or halogen, and R.sub.7 is a hydrogen, lower alkyl or halogen. The vasoconstrictor can be used for a variety of purposes, including hemostasis or the treatment of shock, for example vasodilatory shock syndromes such as septic shock.

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Patent Owner(s)

Patent OwnerAddress
ORGANIX INCWOBURN MA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kunos, George Bethesda, MD 17 94
Razdan, Raj K Gloucester, MA 23 273

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