Specific steady-state R-type CA.sup.2+ channel blockers and use thereof
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United States of America Patent
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Sep 19, 2006
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app pub date -
Nov 7, 2002
filing date -
Jul 20, 2000
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Abstract
The present invention relates to Ca.sup.2+ channel blockers and more particularly to the R-type Ca.sup.2+ channel blockers. More specifically, the invention relates to Ca.sup.2+ channel blockers activity of Mandevilla velutina and Mandevilla illustris. The present invention further concerns saponin-like compounds isolated from Mandevilla species. The present invention also relates to the treatment of several pathologies that involve the nifedipine-insensitive but isradipine sensitive steady-state R-type Ca.sup.2+ channel and the use of steady-state R-type Ca.sup.2+ channel blockers in the treatment of these pathologies.
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