Microfluidic chip with enhanced tip for stable electrospray ionization

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United States of America Patent

PATENT NO 7105812
SERIAL NO

10871498

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Abstract

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A microfluidic chip formed with multiple fluid channels terminating at a tapered electrospray ionization tip for mass spectrometric analysis. The fluid channels may be formed onto a channel plate that are in fluid communication with corresponding reservoirs. The electrospray tip can be formed along a defined distal portion of the channel plate that can include a single or multiple tapered surfaces. The fluid channels may terminate at an open-tip region of the electrospray tip. A covering plate may substantially enclose most portions of the fluid channels formed on the channel plate except for the open-tip region. Another aspect of the invention provides methods for conducting mass spectrometric analysis of multiple samples flowing through individual fluid channels in a single microfluidic chip that is formed with a tapered electrospray tip having an open-tip region.

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Patent Owner(s)

Patent OwnerAddress
NORVIEL VERN1155 EL ABRA SAN JOSE CA 95125

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Blaga, Iuliu Fremont, CA 2 113
Bousse, Luc Los Altos, CA 35 1611
Ni, Jing Sunnyvale, CA 49 419
Stults, John Redwood City, CA 3 112
Zhao, Mingqi San Jose, CA 27 2399

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