Human tumor suppressor gene
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United States of America Patent
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Sep 12, 2006
Grant Date -
Dec 19, 2002
app pub date -
May 16, 2002
filing date -
Apr 21, 1997
priority date (Note) -
Expired
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Abstract
A novel human progestin-regulated gene designated EDD (E3 isolated by Differential Display) is disclosed which encodes a product exhibiting significant amino acid sequence identity with the HYD protein (hyperplastic discs) from Drosophila melanogaster and the 100 kDa HECT (homologous to E6-AP carboxyl terminus) domain protein from rat. The EDD gene appears to represent a tumour suppressor gene and the detection of a polymorphism or alteration in the gene from a subject may be useful for the diagnosis or determination of a predisposition to hyperproliferative disease such as a cancer. An assay for assessing progestin-responsiveness in a subject is also disclosed.
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