Importance

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Abstract

Compositions for the inhibition of the formation of new vaculature by angiogenesis are provided as in compounds which are salts comprising as an acidic component a compound of formula (1) wherein: R.sup.1, R.sup.2 and R.sup.3 are each independently alkyl, R.sup.4 is alkoxy, haloalkoxy, alkyl, haloalkyl, alkenyl, alkynyl, alkylthio, alkylsulphinyl, alkylsulphonyl, hydroxy or halo, R.sup.5 is hydrogen, alkoxy, alkyl, alkylthio, hydroxy, phosphate or halo, and, as the basic component, a compound selected from the group consisting of (2) a compound of formula (2) wherein R.sup.6 is hydrogen or alkyl R.sup.7 is alkyl, alkylamino, dialkylamino, nitroamino, hydrazine, mercapto or alkylthio X is CH.sub.2, CH.sub.2CH.sub.2, CH.sub.2S, CH.sub.2CH.sub.2S Y is NH or S or a compound of formula (3) wherein R.sup.8 is alkyl or aminoalkyl R.sup.9 is hydrogen, alkyl or optionally substituted phenyl or, a compound of formula (4) wherein Z is O, S, CH2, CHR13 or a bond R.sup.10, R.sup.11, R.sup.12 and R.sup.13 are each independently alkyl or hydrogen or, a compound of formula (5) wherein R.sup.14 is alkyl and the pharmaceutically acceptable solvates and hydrates thereof.

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First Claim