Polynucleotide cleavage agent switched on by photo irradiation
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United States of America Patent
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Aug 29, 2006
Grant Date -
Mar 25, 2004
app pub date -
Mar 5, 2003
filing date -
Sep 6, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention provides a polynucleotide cleavage agent switched on by photo-irradiation and a method of cleaving or decomposing a polynucleotide such as DNA or RNA using this agent switched on in this manner. More specifically, said polynucleotide cleavage agent switched on by photo-irradiation comprises cyclopropane or a 2,2-dihalogeno-cyclopropane ring between 'A' unit and 'B' unit, wherein said 'A' unit is an aromatic group having an electron withdrawing property and is excited by photo-irradiation, and said 'B' unit is a hydrophilic functional group. Said polynucleotide cleavage agent may further contain 'C' unit which can recognize DNA sequences, and also a spacer molecule, if desired.
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