Accommodating subject and instrument variations in spectroscopic determinations
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United States of America Patent
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Aug 29, 2006
Grant Date -
Feb 19, 2004
app pub date -
Aug 16, 2002
filing date -
Oct 13, 1998
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Expired
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Abstract
A method and apparatus for measuring a biological attribute, such as the concentration of an analyte, particularly a blood analyte in tissue such as glucose. The method utilizes spectrographic techniques in conjunction with an improved instrument-tailored or subject-tailored calibration model. In a calibration phase, calibration model data is modified to reduce or eliminate instrument-specific attributes, resulting in a calibration data set modeling intra-instrument or intra-subject variation. In a prediction phase, the prediction process is tailored for each target instrument separately using a minimal number of spectral measurements from each instrument or subject.
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