Antibodies to truncated VEGF-D and uses thereof
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United States of America Patent
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Aug 29, 2006
Grant Date -
Jul 22, 2004
app pub date -
Feb 18, 2004
filing date -
Dec 21, 1998
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Abstract
The invention is based on the isolation of antibodies that were made to a polypeptide having the amino acid sequence for a truncated VEGF-D. One of these antibodies can interfere with the activity of VEGF-D mediated by VEGFR-2 and interfere with the binding of VEGF-D to VEGFR-3 but does not interfere with the activity of VEGF mediated by VEGFR-2 or bind to VEGF-C. The invention provides pharmaceutical and diagnostic compositions and methods utilizing these antibodies.
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