Human aggrecanase and nucleic acid compositions encoding the same
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United States of America Patent
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Aug 22, 2006
Grant Date -
May 12, 2005
app pub date -
Sep 17, 2003
filing date -
May 10, 1999
priority date (Note) -
Expired
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Abstract
Human aggrecanase and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting aggrecanase activity in a host and methods of treating disease conditions associated with aggrecanase activity, e.g. rheumatoid arthritis, osteo-arthritis, infectious arthritis, gouty arthritis, psoriatic arthritis, spondolysis, sports injury, joint trauma, pulmonary disease, fibrosis, and the like.
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