Tubulin binding ligands and corresponding prodrug constructs
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United States of America Patent
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Aug 15, 2006
Grant Date -
Mar 4, 2004
app pub date -
Apr 29, 2003
filing date -
Mar 10, 2000
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Abstract
A diverse set of tubulin binding agents have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl-aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin. In phenolic or amino form, these ligands may be further functionalized to prepare phosphate esters, phosphate salts, phosphoramidates, and other prodrugs capable of demonstrating selective targeting and destruction of tumor cell vasculature.
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