Method of screening binding of a compound to a receptor

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United States of America Patent

PATENT NO 7081346
APP PUB NO 20030215959A1
SERIAL NO

10145002

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Abstract

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Disclosed is a method of measuring affinity of a test compound for a receptor protein. The method includes the steps of providing a receptor-ligand complex comprising a receptor and a quinoxaline derivative ligand bound thereto; then contacting the receptor-ligand complex with a test compound, thereby yielding a receptor-test compound complex and an amount of free quinoxaline derivative; and then measuring the amount of the free quinoxaline derivative generated as a result of the previous step. In this fashion, the affinity of the test compound for the receptor can be determined.

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Patent Owner(s)

Patent OwnerAddress
MARQUETTE UNIVERSITYP O BOX 1881 MILWAUKEE WI 53201-1881

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jayaraman, Vasanthi Milwaukee, WI 1 2

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