DNA vaccines for farm animals, in particular bovines and porcines
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United States of America Patent
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Jul 18, 2006
Grant Date -
May 16, 2002
app pub date -
Jan 16, 2001
filing date -
Jan 21, 2000
priority date (Note) -
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Abstract
DNA vaccine against a pathogen affecting farm animals, in particular bovines or porcines, comprising a plasmid containing a nucleotide sequence encoding an immunogen of a pathogen of the animal species considered, under conditions allowing the in vivo expression of this sequence, and a cationic lipid containing a quaternary ammonium salt, of formula ##STR00001## in which R1 is a saturated or unsaturated linear aliphatic radical having 12 to 18 carbon atoms, R2 is another aliphatic radical containing 2 or 3 carbon atoms, and X a hydroxyl or amine group, this lipid being preferably DMRIE.
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