Asthma associated factors as targets for treating atopic allergies including asthma and related disorders
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United States of America Patent
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Jul 11, 2006
Grant Date -
Dec 18, 2003
app pub date -
Dec 11, 2000
filing date -
Dec 9, 1999
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Abstract
This invention relates to methods for treating asthma or allergy in a mammal by administering a 3-aminosteroid compound to a mammal in need thereof. The 3-aminosteroid compound being capable of down regulating the IL-9 pathway and alleviating asthmatic responses to allergen. Exemplary 3-aminosteroid compounds used in the methods of the invention include compounds having the chemical formula (I), wherein X, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 groups are as defined herein. The invention also relates to certain novel compounds of formula (I). Moreover, the invention also provides methods for identifying an immunomodulatory 3-aminosteroid compound.
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