Mouse CXC chemokine receptor

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United States of America Patent

PATENT NO 7074616
SERIAL NO

09367052

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Abstract

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The present invention pertains to a DNA encoding a polypeptide comprising an entire sequence of the amino acid sequence as shown by SEQ ID NO:2 of Sequence Listing or a partial sequence thereof, or a polypeptide comprising the polypeptide described above, wherein any of the polypeptides has an activity of a receptor capable of binding to a murine PBSF/SDF-1; a polypeptide encoded by the DNA described above, wherein the polypeptide has an activity of a receptor capable of binding to a murine PBSF/SDF-1; cells expressing the polypeptide described above and a human CD4 protein; and a method of screening an AIDS onset inhibitor or an HIV-1 infection inhibitor, characterized by the use of the cells described above. According to the present invention, there can be provided a novel murine CXC chemokine receptor gene, a method of screening an HIV-1 infection inhibitor, and the like, each of which is useful in studies of a therapeutic agent for AIDS and the functional mechanism of HIV-1 infection.

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Patent Owner(s)

Patent OwnerAddress
SHIONOGI & CO LTDOSAKA
TADAMITSU KISHIMOTO3-5-31 NAKANO-CHO OSAKA TONDABAYASHI-SHI

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Iizasa, Hisashi Kanazawa, JP 3 3
Kishimoto, Tadamitsu Tondabayashi-shi, Osaka 584, JP 50 2189
Nagasawa, Takashi Sakai, JP 11 101
Nakajima, Toshihiro Toyonaka, JP 68 328
Tachibana, Kazunobu Sakai, JP 4 47
Yoshida, Nobuaki Kashiba, JP 8 67
Yoshie, Osamu Nishinomiya, JP 7 28

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