Methods and means of histone methylation
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United States of America Patent
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Jul 11, 2006
Grant Date -
Dec 2, 2004
app pub date -
May 2, 2002
filing date -
May 8, 2001
priority date (Note) -
Expired
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Abstract
This invention relates to the methylation of histones, in particular to a previously uncharacterised group of histone H3 methylases which comprise a SET domain and which methylate either lysine 4 within the amino tail of histone H3 or within the histone H3 core. Methylation by these methylases, in particular trimethylation, is shown to be important for transcriptional activity.
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