Aryl phosphate derivatives of AZT having anti-HIV activity
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United States of America Patent
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Jul 4, 2006
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N/A
app pub date -
Dec 1, 2003
filing date -
Jun 29, 1998
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Expired
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Abstract
Aryl phosphate derivatives of d4T with para-bromo substitution on the aryl group show markedly increased potency as anti-HIV agents without undesirable levels of cytotoxic activity. In particular, these derivatives are potent inhibitors of HIV reverse transcriptase. In a preferred aspect of the present invention, the phosphorus of the aryl phosphate group is further substituted with an amino acid residue that may be esterified or substituted, such as a methoxy alaninyl group.
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