Protein that enhances expression of potassium channels on cell surfaces and nucleic acids that encode the same
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United States of America Patent
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Jun 13, 2006
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Feb 13, 2002
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Apr 17, 1998
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Abstract
The present invention provides polynucleotides that encode a protein, designated herein as K+ Channel Associated Protein or 'KChAP'. It has been determined that expressing polynucleotides that encode KChAP in host cells, along with polynucleotides that encode the Kv.alpha. channel subunit Kv 2.1, the Kv.alpha. channel subunit Kv 2.2, the Kv.alpha. channel subunit Kv 1.3, or the Kv.alpha. channel subunit Kv 4.3, increases the number of Kv2.1, Kv 2.2, Kv1.3 or Kv4.3 channels, respectively, in the plasma membrane of such cells. The present invention also relates to a method of making cells that have increased numbers of Kv channels on the plasma membranes thereof and to a method of using such cells as model systems for studying the effect of pharmacological agents on Kv channels, particularly on Kv2.1, Kv 2.2, Kv 1.3, and Kv 4.3 channels. The present invention also relates to the protein KChAP.
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