Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis
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United States of America Patent
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Jun 13, 2006
Grant Date -
Dec 30, 2004
app pub date -
Apr 6, 2004
filing date -
Nov 28, 2000
priority date (Note) -
Expired
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Abstract
Disclosed herein is a composition and a method for the treatment of otitis media and paranasal sinusitis using human defensins, lysozyme and/or lactoferrin as a new class of non-antibiotic antimicrobials. From studies of otitis media and paranasal sinusitis, it was observed that certain innate immune modulators were important in the bodies response to the infection. Therefore, these innate immune modulators, lysozyme, lactoferrin, and defensins were tested for use as a non-antibiotic treatment for infection, particularly infections such as otitis media and sinusitis.
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