Fusion proteins for prodrug activation
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United States of America Patent
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Jun 13, 2006
Grant Date -
Jun 6, 2002
app pub date -
Dec 12, 1997
filing date -
Oct 2, 1992
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolize a compound (prodrug) which has little or no cytotoxicity to a cytotoxic compound (drug), where the antigen binding region is composed of a single polypeptide chain. It is advantageous for covalently bonded carbohydrates to be present on the polypeptide chain.
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