Target specific screening and its use for identifying target binders
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United States of America Patent
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Jun 6, 2006
Grant Date -
Sep 25, 2003
app pub date -
Oct 24, 2002
filing date -
Oct 24, 2001
priority date (Note) -
Expired
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Abstract
The invention relates to a modified phage display method for detecting and identifying target and target binders. The modified methods involve transforming host cells with two separate phages of a target or target library and a target-binder library, and selecting to eliminate the non-paired targets and binders. The invention also relates to antibodies that bind to complexes of target and target binders; nucleic acids encoding target and target binders peptides; and the use of sequence information inherent in the targets and target binders for target validation using in silico approaches. The invention further relates to diagnostics and therapeutics employing the disclosed target and target binder peptides or polynucletides and their use in small molecule drug discovery; diagnostic and therapeutic applications directed to cancers and similar disorders; and site directed assays for high throughput drug screening.
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