Importance

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Abstract

The invention relates to new 2,3-benzodiazepine derivatives of general Formula (I), (wherein R.sup.1 stands for methyl, formyl, carboxy, cyano, --CH.dbd.NOH, --CH.dbd.NNHCONH.sub.2 or --NR.sup.5R.sup.6, wherein R.sup.5 and R.sup.6 independently from each other represent hydrogen or lower alkyl or together with the nitrogen atom, they are attached to, form a 5- or 6-membered, saturated or unsaturated heterocyclic ring optionally containing one or more further nitrogen, sulfur and/or oxygen atom(s); R.sup.2 is nitro or amino; R.sup.3 stands for hydrogen, lower alkanoyl or CO--NR.sup.7R.sup.8, wherein R.sup.7 and R.sup.8 independently from each other stand for hydrogen, lower alkoxy, lower alkyl or lower cycloalkyl or together with the nitrogen atom, they are attached to, form a 5- or 6-membered, saturated or unsaturated heterocyclic ring optionally containing one or more further nitrogen, sulfur and/or oxygen atom(s); R.sup.4 is hydrogen or lower alkyl; the dotted lines have the following meaning: if R.sup.3 and R.sup.4 are not present, the bond between positions C.sup.8 and C.sup.9 is a single bond and the bond between positions C.sup.8 and N.sup.7 is a double bond; if R.sup.3 and R.sup.4 are present, the bonds between positions C.sup.8 and C.sup.9 and between position C.sup.8 and N.sup.7 are single bonds; and if R.sup.3 is present and R.sup.4 is missing, the bond between positions C.sup.8 and C.sup.9 is a double bond and the bond between positions C.sup.8 and N.sup.7 is a single bond) and salts thereof. The invention compounds have neuroprotective effect.

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First Claim