Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression
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United States of America Patent
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May 30, 2006
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N/A
app pub date -
Sep 1, 1998
filing date -
Sep 2, 1997
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Expired
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Abstract
The present invention identifies a protein, designated the D-sequence-binding protein (D-BP), is phosphorylated at tyrosine residues and blocks AAV-mediated transgene expression in infected cells by inhibiting the leading strand viral DNA synthesis. More particularly, the present invention demonstrates that D-BP is phosphorylated by EGF-R protein tyrosine kinase. Methods of increasing transcription and promoting replication of transgenes exploiting this information are disclosed herein.
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