Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use
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United States of America Patent
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May 23, 2006
Grant Date -
Jun 24, 2004
app pub date -
Dec 20, 2002
filing date -
Dec 20, 2001
priority date (Note) -
Expired
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Abstract
The invention provides twenty-one butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition.
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