Pyrimidine derivatives as IL-8 receptor antagonists
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United States of America Patent
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May 2, 2006
Grant Date -
May 6, 2004
app pub date -
Jan 10, 2003
filing date -
Jul 15, 1999
priority date (Note) -
Expired
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Abstract
Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula I ##STR00001## In these compounds, Q is preferably unsubstituted and substituted heterocyclyl; U is usually hydrogen or fluorine; and V is preferably hydrogen, halogen, alkyl, --O--alkyl or --S-alkyl. A representative example is: ##STR00002##
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