Composition and method for treating graft-versus-host disease

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United States of America Patent

PATENT NO 7037900
SERIAL NO

09976468

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Abstract

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Compositions and methods are provided for prevention and clinical treatment of various forms of graft-versus-host disease (GVHD) by using inhibitors of adenosine deaminase (ADA). In particular, various formulations and dosing regimens of ADA inhibitors such as pentostatin are provided for the treatment of humans in vivo as well as for ex vivo conditioning of organ transplants in order to specifically suppress T-lymphocyte mediated immune responses while minimizing systemic toxicity of the drug.

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Patent Owner(s)

Patent OwnerAddress
MAYNE PHARMA (USA) INCMACK CALI CENTRE II 650 FROM ROAD 2ND FLOOR PARAMUS NJ 07652

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
DiMartino, Jorge San Carlos, CA 18 129
Nelson, John Tippett Danville, CA 3 15

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