Human thrombopoietin comprising glycosylation sited at residues 157 and 164
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United States of America Patent
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May 2, 2006
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app pub date -
Jan 26, 2005
filing date -
Jun 30, 1998
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Expired
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Abstract
The present invention relates to novel human thrombopoietin (hTPO) derivatives, and to process of preparation thereof. Particularly, sugar chains are introduced into native hTPO by substituting amino acids such as asparagine for amino acids at specific positions in native hTPO, preparing novel hTPO derivatives with high activities enhancing the platelet production in vivo. Therefore, the novel hTPO derivatives of this invention may be useful for the treatment of thrombocytopenia associated with anticancer therapy or the transplantation of bone marrow.
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