Polymeric thiol-linked prodrugs
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United States of America Patent
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Apr 25, 2006
Grant Date -
Aug 7, 2003
app pub date -
Nov 8, 2002
filing date -
Nov 9, 2001
priority date (Note) -
Expired
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Abstract
Thiol-linked polymeric prodrugs and methods of making and using the same are disclosed. The use of a sulfhydryl bond as the basic link for linking the polymer to the drug allows a prodrug to be formed which takes advantage of plasma enzymes in vivo. A preferred conjugate is ##STR1##
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