Formulation, solubilization, purification, and refolding of tissue factor pathway inhibitor
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United States of America Patent
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Apr 4, 2006
Grant Date -
Sep 26, 2002
app pub date -
Nov 30, 2001
filing date -
Jun 7, 1995
priority date (Note) -
Expired
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Abstract
A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0.2 mg/mL and above 10 mg/mL.
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