Process for the synthesis of pergolide
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United States of America Patent
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Mar 28, 2006
Grant Date -
Jun 9, 2005
app pub date -
Mar 10, 2003
filing date -
Mar 15, 2002
priority date (Note) -
Expired
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Abstract
A process for the synthesis of pergolide (Formula (I)) (D-6-n-propyl-8βmethylmercaptomethylergo line) from acid 9,10-dihydrolysergic is herein disclosed. The process can be carried out without isolating most intermediates and is particularly convenient both from the yield and safety standpoint. Moreover, pergolide thereby obtained is highly pure and can be conveniently transformed into pergolide mesylate ##STR1##
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