Mutated herpes simplex virus type 1 thymidine kinases and uses thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 7018834
APP PUB NO 20030202964A1
SERIAL NO

10457604

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Abstract

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The present invention provides new site-specific HSV-thymidine kinase mutants with improved nucleoside analog metabolizing activity due to low or no thymidine phosphorylation ability. Also provided is a method of killing target cells using such mutants combined with a prodrug.

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Patent Owner(s)

Patent OwnerAddress
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSASLITTLE ROCK AR 72207

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Compadre, Cesar Little Rock, AR 14 97
Drake, Richard Little Rock, AR 5 40
Hinds, Trenton Portsmouth Commonwealth, DM 3 13
Hurlburt, Barry Little Rock, AR 3 13
Rechtin, Tammy Birmingham, AL 3 13

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