Process for the production of oxandrolone

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United States of America Patent

PATENT NO 7009063
SERIAL NO

10852744

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Abstract

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The present invention relates to a process for the synthesis of oxandrolone from mestanolone. The process comprises the steps of: (a) oxidizing mestanolone to form 17β-hydroxy-17α-methyl-5α-androst-1-en-3-one; (b) hydroxylating the 17β-hydroxy-17α-methyl-5α-androst-1-en-3-one to form 1α, 2α, 17β-trihydroxy-17α-methylandrostan-3-one; (c) cleaving the 1α, 2α, 17β-trihydroxy-17α-methylandrostan-3-one to form 17β-hydroxy-17α-methyl-1-oxo-1,2,-seco-A-nor-5α-androstan-2-oic acid; and (d) reducing the 17β-hydroxy-17α-methyl-1-oxo-1,2,-seco-A-nor-5α-androstan-2-oic acid to form oxandrolone.

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Patent Owner(s)

Patent OwnerAddress
BARR LABORATORIES INCWOODCLIFF LAKE NEW JERSEY 07677

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Desai, Shaileshkumar Ramanlal Wilmington, NC 5 2
Ray, Jr David Wayne Wilmington, NC 2 1
Sayed, Yousry A Wilmington, NC 2 1

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